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Foxm1 in cancer

WebApr 13, 2024 · In research published in The Journal of Clinical Investigation and in Breast Cancer Research and Treatment, Benita and John describe a new inhibitory compound … WebExpression and functional characterization of FOXM1 in non-small cell lung cancer Yan Zhang, Wen-bin Qiao, Li Shan Department of Thoracic Oncology, Tumor Hospital …

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WebApr 13, 2024 · In research published in The Journal of Clinical Investigation and in Breast Cancer Research and Treatment, Benita and John describe a new inhibitory compound that blocks the Forkhead box protein M1 (FOXM1), a protein that plays a critical role in tumor cell growth and metastasis. WebJan 31, 2024 · Objective . The aim of the present study was to investigate the effect of forkhead box M1 (FOXM1) to paclitaxel resistance in cervical cancer cells, to determine the underlying mechanism, and to identify novel targets for the treatment of paclitaxel-resistant cervical cancer. Methods . Paclitaxel-resistant Caski cells (Caski/Taxol cells) were … scentsational meaning https://passion4lingerie.com

Biology of FOXM1 and its emerging role in cancer therapy

WebExpression and functional characterization of FOXM1 in non-small cell lung cancer Yan Zhang, Wen-bin Qiao, Li Shan Department of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Xinjiang, People’s Republic of China Objectives: FOXM1 is a key member of the FOX transcription factor family, which plays a vital role in a series of … WebJul 11, 2024 · The Forkhead box protein M1 (FoxM1) is an appealing target for anti-cancer therapeutics as this cell proliferation-associated transcription factor is overexpressed in most human cancers. FoxM1 is involved in tumor invasion, angiogenesis, and metastasis. To discover novel inhibitors that disrupt the FoxM1-DNA interaction, we identified CDI, a … WebFeb 29, 2012 · In this study, we examined whether FOXM1 plays a role in cell death induced by DNA-damage in human tumor cell lines with mutant p53. We demonstrate that stable … scentsational hand sanitizer

FOXM1 Inhibition Enhances the Therapeutic Outcome of Lung …

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Foxm1 in cancer

FOXO transcription factor family in cancer and …

WebMar 5, 2013 · FoxM1 has been reported to modulate drug sensitivity and resistance in various tumor types. In breast cancer cell lines with acquired resistance for cisplatin or epirubicin FoxM1 was found to be overexpressed and its depletion was able to re-sensitize these cell lines to the respective genotoxic drug ( Kwok et al., 2010; Monteiro et al., 2012 ). WebNov 3, 2012 · The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance.

Foxm1 in cancer

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WebMar 7, 2014 · FOXM1 is a transcription factor that transactivates AURKA and other G2/M genes like PLK1, CDK1, and CCNB1 (16) (17) (18). High FOXM1 expression was reported in many cancers including oral... WebThe knockdown of FOXM1 also attenuated proliferation and induced G1 arrest in lung cancer cells. Conclusion: CENPU was highly expressed in NSCLC tissues, wherein it promoted lung cancer cell proliferation via the transcription factor, FOXM1, which could be a potential target for therapeutic strategies.

WebOur meta-analysis included nine studies and 1,686 patients, suggesting that overexpression of FoxM1 predicted a poor 3-year, 5-year overall survival. Moreover, the results also … WebAug 17, 2024 · The nuclear translocation of FOXM1 has been highlighted as a prominent feature of many cancers. We investigated FOXM1 enrichment in the nuclei of pFLAG …

WebJun 11, 2024 · Excessive upregulation of FOXM1 can stimulate gene transcription, ultimately resulting in oncogenesis and malignant tumor progression. In addition, upregulated FOXM1 expression can inhibit apoptosis of lung cancer cells and promote their proliferation. WebNov 1, 2024 · The main role of FOXM1 is to contribute to stemness in several malignancies. It regulates number, maintenance, renewal, and tumorigenicity of CSCs through cross-talk with various pathways ( Table 1 ). FOXM1 increases the DNA repair by increasing the expression of genes involved in it.

WebOverexpression of FOXM1 has been reported in more than 20 types of human cancer. In recent years, FOXM1 has been implicated in diverse cellular processes and also a …

WebJul 14, 2024 · FOXM1 inhibition efficiently sensitizes cancer cells to conventional chemotherapy, yet the often unknown inhibitory pathways of these compounds or their … scentsationals 20 watt replacement wax warmerWebJul 11, 2024 · The Forkhead box protein M1 (FoxM1) is an appealing target for anti-cancer therapeutics as this cell proliferation-associated transcription factor is overexpressed in … scentsational products venice flWebJun 8, 2011 · Consistent with this notion, FOXM1 has been found to be frequently upregulated in a host of human cancers, including colorectal ( 23 ), lung ( 24 ), prostate ( 25 ), liver ( 26 ), stomach ( 38 ), breast ( 27 ), and basal cell carcinomas ( 39) as well as glioblastoma ( 40 ). run you foolsWebJun 14, 2024 · FOXM1A is a transcriptional repressor that locates in cytoplasm. FOXM1C is a transcriptional activator overexpressed in some tumors, and FOXM1D predominantly … run your church sound system through obsWebMay 7, 2024 · Here, we show that FOXM1 is more highly expressed in fibrotic than in normal lung fibroblasts in humans and mice. FOXM1 was required not only for cell proliferation in response to mitogens, but also for myofibroblast differentiation and apoptosis resistance elicited by TGF-β. run you chicken fat runWebMay 5, 2024 · FOXM1 can counteract oxidative stress–induced senescence through enhancing the transcription of the cell self-renewal Bmi-1 gene [ 32 ]. Moreover, inhibition of FOXM1 in cancer cells, such as those of … run your city 10kWebDec 1, 2024 · FOXM1 is a master regulator in cancer 25 and promotes cancer progression through many pathways including key roles in tumor proliferation, cell cycle progression, DNA damage repair, angiogenesis ... scentsationals 15w light bulbs