Dynein intermediate chain
WebDec 8, 2024 · Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2 cl29593 Location: 266 → 589 WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 … WebJan 20, 2024 · These local maps and their merged composites (Supplementary Table 1) allowed us to place models of all three heavy chains (α-HC, β-HC, and γ-HC), both intermediate chains (IC1 and IC2), 8 of ...
Dynein intermediate chain
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WebAug 1, 2011 · Dynein light chain (LC) subunits are conserved across species; however, the molecular contribution of LCs to dynein function remains controversial. One model suggests that LCs act as cargo-binding scaffolds. Alternatively, LCs are proposed to stabilize the intermediate chains (ICs) of the dynein complex. WebCytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein …
WebCoordinated movement of the dynein arms causes the entire axoneme to bend back and forth. IDAs and ODAs have different combinations of protein components (subunits) that … WebJan 1, 2024 · Cytoplasmic , and axonemal dynein are multiple component complexes that share some common features but participate in fundamentally different processes …
Each molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), is a dimer of dimers, containing approximately twelve polypeptide sub… WebCytoplasmic dynein 1 is a multisubunit complex of ∼1.5 MDa composed of a homodimer of heavy chains (encoded by DYNC1H1), two intermediate chains (encoded by DYNC1I1 and DYNC1I2), light-intermediate chains (encoded by DYNC1LI1, DYNC1LI2) and light chains (encoded by DYNLT1, DYNLT3, DYNLRB1, DYNLRB2, DYNLL1, DYNLLl2).
Web1 day ago · Outer dynein arms in the ciliary axoneme generate force for ciliary beating. Here, cryo-electron tomography study of the outer dynein arm from the unicellular alga …
WebNov 1, 2006 · Isoforms of the intermediate chain (IC) family bind to some axonemal dyneins and cytoplasmic dynein 1 but not cytoplasmic dynein 2. ... The third P-loop domain in cytoplasmic dynein heavy chain is essential for dynein motor function and ATP-sensitive microtubule binding. Mol. Biol. Cell. 14, 1355-1365. Summers, K. E. and Gibbons, I. R. … tsume x toboe fanfictionWebOct 1, 2014 · The LIC domain structure has interesting parallels with the dynein intermediate chain, which has a well-ordered WD repeat domain that interacts with the heavy chain and a less conserved disordered … phl to yellowstone national parkphl to xnaWebThe dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully understood. Previous work has established that the LIC homodimer binds directly to the dynein heavy chain and may mediate the attachment of dynein to centrosomes and other cargoes. Here, we ... tsum good for feverWebThe deduced protein contains a P-loop near the N terminus. Using primers based on mouse and chicken dynein Lic1, Bielli et al. (2001) amplified human DYNC1LI1, which they called LIC1, from a placenta cDNA library. The deduced 515-amino acid protein has a calculated molecular mass of 56.6 kD. It contains 2 probable alpha-helical domains flanking ... phl to yegWebMar 4, 2024 · Coil: yellow. Ribbons are thickened and non-physical struts added to make more robust for 3D printing. 6f1y-ribbon-rainbow-vis. Molecular ribbon representation with each biopolymer chain colored by rainbow from N-terminus (red) to C-terminus (blue). Intended for visualization only, not 3D printing. tsum good for time bubblesWebThe dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully understood. Previous work … tsumi genshin impact