Breast cancer resistance protein 意味
WebJun 29, 2015 · 通过分析人Topo II 的ATPase结构域的晶体结构， 我们发现大黄素通过形成极性的氢键来结合至ATPase 结构域，这与大黄素能够抑制ATP 解和大黄素通过与ATP竞争结合至Topo II 的ATP结合位点的结果相一致（图 这些发现意味着大黄素作为ATP的竞争抑制剂抑制了Topo II 的活性。 WebP-glycoprotein. P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is a cell membrane protein that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with ...
Breast cancer resistance protein 意味
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WebApr 11, 2024 · 251.Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome. 过多的核糖体蛋白生产使脆性X综合征模型中的翻译失衡。 252.Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer. WebApr 30, 2024 · In addition to the altered metabolism of cancer cells, exosomes contributing to the tumor microenvironment are worth being investigated for the discovery of biomarkers and for the development of novel drug delivery systems. This Special Issue focuses on the molecular basis of drug resistance in cancer and on MDR reversal agents, with the aim …
WebIntroduction. Breast cancer resistance protein (BCRP)/ABCG2/MXR/ABCP is a member of the ATP-binding cassette superfamily of transporters present on cell membranes, which was first identified in Adriamycin resistant breast cancer cell lines (MCF-7/AdrVp) ().It was found to confer resistance to mitoxantrone, doxorubicin, and daunorubicin as it reduced … WebApr 1, 2002 · Abstract. Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of interest as chemosensitizers for clinical drug resistance, for improving the pharmacokinetics of substrate chemotherapeutic drugs, and in functional assays of BCRP activity for tailoring chemotherapy. The fungal toxin fumitremorgin C …
WebAug 24, 2024 · BCRP: breast cancer resistance protein; MATE: multidrug and toxin extrusion protein; MRP2: multidrug resistance-associated protein 2; OAT: organic anion transporter; OATP: organic anion ... WebApr 14, 2024 · When it comes to endocrine resistance, estrogen withdrawal can activate UPR (unfolded protein response) , leading to the release of glucose-regulated protein …
WebThe most well known genes associated with increased breast cancer risk are BRCA1 and BRCA2. Women with abnormal BRCA1 or BRCA2 experience up to a 60% risk to develop breast cancer by the age of 90. Other risk factors include early menarche and late menopause. Pregnancy has been reported to decrease risk, probably due to the …
WebDec 2, 2024 · 三个皮匠报告网每日会更新大量报告，包括行业研究报告、市场调研报告、行业分析报告、外文报告、会议报告、招股书、白皮书、世界500强企业分析报告以及券商报告等内容的更新，通过行业分析栏目，大家可以快速找到各大行业分析研究报告等内容。 past tense of build upWebbreast cancer resistance protein - 1000万語の英語の意味を収録！Weblio英和・和英辞書 ... 「breast cancer resistance protein」の意味に関連した用語 ... tiny house builders in kyWebThe recent demonstration that addiction-relevant neuronal ensembles defined by known master transcription factors and their connectome is networked throughout past tense of breakingWeb1 day ago · The research could lead to new therapies that have fewer side effects and work against cancers that have grown resistant to existing treatments. About 250,000 women … past tense of cleanedThis protein is a member of the White subfamily. Alternatively referred to as the breast cancer resistance protein (BCRP), this protein functions as a xenobiotic transporter which may play a role in multi-drug resistance to chemotherapeutic agents including mitoxantrone and camptothecin analogues. See more ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation … See more It is inhibited by some calcium channel blockers such as amlodipine, felodipine and nifedipine. The fungal toxin fumitremorgin C (FTC) inhibits the protein but has neurotoxic side … See more • ABCG2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Human ABCG2 genome location and ABCG2 gene details page in the See more The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The active transport of chemicals … See more • ATP-binding cassette transporter See more • Hazai E, Bikádi Z (April 2008). "Homology modeling of breast cancer resistance protein (ABCG2)". Journal of Structural Biology. 162 (1): 63–74. doi: • Abbott BL (January 2006). … See more past tense of cleavageWebJun 1, 2024 · Breast cancer resistance protein (BCRP) is expressed on the apical membrane of small intestinal epithelial cells and functions as an efflux pump with broad substrate recognition. Therefore, quantitative evaluation of the contribution of BCRP to the intestinal permeability of new chemical entities is very important in drug research and … past tense of burn burned or burntWebATP binding cassette (ABC)-containing drug efflux transporters play important roles in regulating intracellular drug concentrations that determine cell sensitivity to chemotherapeutic agents. Of particular relevance to … past tense of catch in a sentence